Casey T. Weaver, MD

Pham, D., D.J. Silberger, M. Gao, K.N. Nguyen, R.D. Hatton+, and C.T Weaver+. Batf stabilizes the Th17 cell developmental program through impairment of Stat5-dependent recruitment of Ets1-Runx1 complexes. EMBO J (in revision).

Zindl, C.L., S.J. Witte, V.A. Laufer, M. Gao, Z. Yue, Daniel J. Silberger, S.N. Harbour, J.R. Singer, Duy Pham, C.E. Moseley, B. Cai, H. Turner, F.E. Lund, B.A. Vallance, A.F. Rosenberg, J.Y. Chen, R.T. Hatton1 and C.T. Weaver. A non-redundant role for T cell-derived IL-22 in antibacterial defense of colonic crypts. Immunity 55:494-511, 2022.

Kahan. S.M., R.K. Bakshi, J.T. Ingram, R.C. Hendrickson, E.J. Lefkowitz, D.K. Crossman, L.E. Harrington, C.T. Weaver, and A.J. Zajac. Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection. Science Immunology 7:eabl6322, 2022.

Chen, M.L., X. Huang, H. Wang, C. Hegner, Y. Liu, J. Shang, A. Eliason, H. Diao, H. Park, B. Frey, G. Wang, S.A. Mosure, L.A. Solt, D.J. Kojetin, A. Rodriguez-Palacios, D.A. Schady, C.T. Weaver, M.E. Pipkin, D.D. Moore, and M.S. Sundrud. CAR directs T cell adaptation to bile acids in the small intestine. Nature 593:147-151, 2021.

Glover ME, Cohen JL, Singer JR, Sabbagh MN, Rainville JR, Hyland MT, Morrow CD, C.T. Weaver, Hodes GE, Kerman IA, and SM Clinton. Examining the role of microbiota in emotional behavior: antibiotic treatment exacerbates anxiety in high-anxiety-prone male rats. Neuroscience, 459:179-197, 2021.

Moldoveanu Z., H. Suzuki, C. Reily, K. Satake, L. Novak, N. Xu, Z.Q. Huang, B. Knoppova, A. Khan, S. Hall, H. Yanagawa, R. Brown, C.J. Winstead, D.B. O'Quinn, A. Weinmann, A.G. Gharavi, K. Kiryluk, B.A. Julian, C.T. Weaver, Y. Suzuki, and J. Novak. Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy. J. Autoimmun. 118:102593, 2021.

C.T. Weaver. One road to the TH17 pathway: How TH1 led to TH17 (and vice versa), and first became last. Nature Immunology 21:819-821, 2020.

Camacho, V., V.R. Matkins, S.B. Patel, J.M.Lever, Z. Yang, L. Ying, A.E. Landuyt, E.C. Dean, J.F. George, H. Yan, P.B. Ferrell, C.L. Maynard, C.T. Weaver, H.R. Turnquist, and R.S. Welner. Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10. J. Clin. Invest. Insight 5:e135681, 2020.

Harbour, S.N., D.F. DiToro, S.J. Witte, C.L. Zindl, T.R. Schoeb, G.W. Jones, S.A. Jones, R.D. Hatton, and C.T. Weaver. Th17 cells require ongoing classical IL-6 receptor signaling to retain transcriptional and functional identity. Science Immunology 5:eeaw2262, 2020.

DiToro, D.F., S.N. Harbour, Steven Witte, Vincent Laufer, M. Gao, C.E. Moseley1, H. Turner, J. Bruning, C.H. Conover,, R.D. Hatton, S.J. Frank5, and C.T. Weaver. Insulin-like growth factors are key regulators of Th17-Treg cell balance in autoimmunity. Immunity 52:650-667, 2020.

Evonuk, K.S., R.E. Doyle, C.E. Moseley, I.M. Thornell, K. Adler, A.M. Bingaman, M.O. Bevensee, B. Min, C.T. Weaver, and T.M. DeSilva. Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammatyion. Sci Adv 6:eaax5936, 2020.

Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.