Matthew E. Pipkin, Ph.D.

Diao H, Chen R, Tsuda SM, Wang D, Frederick MA, Kim J, Karunadharma P, Martinez GJ, Getzler AJ, Toma C, Milner JJ, Venables TC, Martin DM, Goldrath AW, Crotty S, Pipkin ME. Single-cell lineage trajectories and chromatin regulators that initialize antiviral CD8 T cell ontogeny. In revision. Available via bioRxiv:

Milner JJ, Toma C, Quon S, Omilusik K, Scharping NE, Dey A, Reina-Campos M, Nguyen H, Getzler AJ, Diao H, Yu B, Delpoux A, Yoshida TM, Li D, Qi J, Vincek A, Hedrick SM, Egawa T, Zhou MM, Crotty S, Ozato K, Pipkin ME, Goldrath AW. Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection. J Exp Med. 2021 Aug 2;218(8):e20202512. doi: 10.1084/jem.20202512. PMID: 34037670

Tsuda S, Pipkin ME. Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells. Cold Spring Harb Perspect Biol. 2021 Jun 14:a037945. doi: 10.1101/cshperspect.a037945. PMID: 34127445

Xu T, Schutte A, Jimenez L, Gonçalves ANA, Keller A, Pipkin ME, Nakaya HI, Pereira RM, Martinez GJ. Kdm6b Regulates the Generation of Effector CD8 + T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes. J Immunol. 2021 May 1;206(9):2170-2183. doi: 10.4049/jimmunol.2001459. Epub 2021 Apr 16. PMID: 33863789.

Chen ML, Huang X, Wang H, Hegner C, Liu Y, Shang J, Eliason A, Diao H, Park H, Frey B, Wang G, Mosure SA, Solt SA, Kojetin DJ, Rodriguez-Palacios A, Schady DA, Weaver CT, Pipkin ME, Moore DD*, and Sundrud MS*. CAR directs T cell adaptation to bile acids in the small intestine. Nature, 2021 April 7. doi: 10.1038/s41586-021-03421-6. PMID: 33828301.

Pipkin ME. Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development. Immunol Rev. 2021 Mar;300(1):100-124. doi: 10.1111/imr.12954. PMID: 33682165

Mori L, Jenike K, Yeh YHJ , Lacombe B, Li C, Getzler A, Mediouni S, Cameron M, Pipkin ME, Ho YC, Ramirez BC, Valente S. The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency. J Virol. 2020 Nov 25;95(4):e01247-20. doi: 10.1128/JVI.01247-20

Choi J, Diao H, Faliti CE, Truong J, Rossi M, Bélanger S, Yu B, Goldrath AW, Pipkin ME, Crotty S. Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits. Nat Immunol. 2020 Jul;21(7):777-789. doi: 10.1038/s41590-020-0706-5. PubMed PMID: 32572238.

Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.