Boris Striepen, PhD

Gibson A.R., Sateriale A., Dumaine J.E., Engiles J.B., Pardy R.D., Gullicksrud J.A., O'Dea, K., Beiting, D. P., Hunter, C.A., and Striepen, B. (2022) A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. PLoS Pathogens 18: e1010003.

English, E.D., Guerin, A, Tandel, J. and Striepen, B. (2022) Live imaging of the Cryptosporidium parvum lifecycle reveals direct development of male and female gametes from type I meronts. PLoS Biology 20: e3001604.

Dumaine, J.E., Sateriale, A., Gibson, A.R., Redy, A., Gullicksrud, J.A., Hunter, E., and Striepen, B. (2021) The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell. eLife. e70451.

Gullicksrud, J.A., Sateriale, A., Engiles, J.B., Gibson, A., Shaw, S., Hutchins, Z.A., Martin, L., Christian, D., Taylor, G.A., Yamamoto, M., Beiting, D.P., Striepen, B., and Hunter, C.A. (2022) Crosstalk between enterocytes and innate lymphoid cell drives early IFN-γ-mediated control of Cryptosporidium. Mucosal Immunity 15: 362-372.

Guérin, A., Roy, N.H., Kugler, E.M., Berry, L., Burkhardt, J.K., Shin, J.-B., and Striepen, B. (2021) A screen for Cryptosporidium rhoptry proteins identifies ROP1 as an effector targeting the host cytoskeletal modulator LMO7. Cell Host & Microbe 29: 1-14.

Sateriale, A., Gullicksrud, J.A., Engiles, J.B., McLeod, B., Kugler, E.M., Henao-Mejia, J., Zhou, T., Ring, A.M., Brodsky, I.E., J.C. Hunter, C.A., and Striepen, B. (2021) The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6. Proc. Natl. Acad. Sci. U.S.A. 118: e2007807118.

Guérin, A., and Striepen, B. (2020) The Biology of the intestinal intracellular parasite Cryptosporidium. Cell Host & Microbe 28: 509-515.

Vinayak, S., Jumani, R.S., Miller, P., Hasan, M.M., McLeod, B., Tandel, J., Stebbins, E.E., Teixeira, J.E., Borrel, J., Gonse, A., Zhang, M., Yu, X., Wernimont, A., Walpole, C., Eckley, S., Love, M.S., McNamara, C. W., Sharma, M., Sharma, A., Kato, N., Schreiber, S.L., Melillo, B., Striepen*, B., Huston*, C.D., and Comer*, E. (2020) Phenylalanyl-tRNA synthetase (PheRS), a novel drug target for Cryptosporidium: discovery of therapeutically relevant inhibitors with genetic, biochemical and chemical target validation. *co-corresponding authors. Science Transl. Med. 12, eaba8412

Pawlowic, M., Somepalli, M., Sateriale, A., Herbert, G.T. Gibson, A.R., Cuny, G., Hedstrom, L., and Striepen, B. (2019) Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell. Proc. Natl. Acad. Sci. U.S.A. 116: 21160-21165.

Tandel, J., English, E., Sateriale, A., Gullicksrud, J., Beiting, D.P., Sullivan, M.C., Pinkston, B., and Striepen, B. (2019) Lifecycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum. Nature Microbiology 4: 2226-2236

Sateriale, A., Slapeta, J., Baptista, R., Engiles, J.B., Gullicksrud, J.A., Herbert, G.T., Brooks, C.F., Kugler, E.M., Kissinger, J.C. Hunter, C.A., and Striepen, B. (2019) A genetically tractable, natural mouse model of cryptosporidiosis offers insights into host protective immunity. Cell Host & Microbe 26, 135–146

Manjunatha, U.H.†, Vinayak, S.†, Zambriski, J.A.*†, Chao, A.T., Sy, T., Noble, S.J., Bonamy, G., Kondreddi, R.R., Zou, B., Gedeck, P., Brooks, C.F., Herbert, G.T., Sateriale, A., Tandel, J., Noh, S., Lakshminarayana, S.B., Lim, S.H., Goodman, L.B., Yeung, B.K.S., Bodenreider, C., Feng, G., Zhang, L., Blasco, F., Wagner, J., Leong. F.J., Striepen, B.*, and Diagana T. * (2017) An inhibitor of the Cryptosporidium PI(4)K is a candidate drug for cryptosporidiosis. Nature 546: 376-380 (*equal contribution)

Vinayak, S.*, Pawlowic, M.C.*, Sateriale, A*, Brooks, C.F., Studstill, J.C., Bar-Peled, Y., Cirpriano, M.J. and Striepen, B. (2015) Genetic modification of the diarrheal pathogen Cryptosporidium parvum. Nature 523: 477–480 (*equal contribution)

Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.