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Publications

Gunnar C. Hansson & Malin E. Johansson

Schneider H, Berger E, Dolan B, Martinez-Abad B, Arike L, Pelaseyed T, Hansson GC. The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. Biochem J. 2019 Aug 22;476(16):2281-2295. doi: 10.1042/BCJ20190180. PubMed PMID: 31387973; PubMed Central PMCID: PMC6705488.

Volk JK, Nyström EEL, van der Post S, Abad BM, Schroeder BO, Johansson Å, Svensson F, Jäverfelt S, Johansson MEV, Hansson GC, Birchenough GMH. The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function. J Exp Med. 2019 Aug 16. pii: jem.20190679. doi: 10.1084/jem.20190679. PubMed PMID: 31420376.

Blacher E, Bashiardes S, Shapiro H, Rothschild D, Mor U, Dori-Bachash M, Kleimeyer C, Moresi C, Harnik Y, Zur M, Zabari M, Brik RB, Kviatcovsky D, Zmora N, Cohen Y, Bar N, Levi I, Amar N, Mehlman T, Brandis A, Biton I, Kuperman Y, Tsoory M, Alfahel L, Harmelin A, Schwartz M, Israelson A, Arike L, Johansson MEV, Hansson GC, Gotkine M, Segal E, Elinav E. Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature. 2019 Aug;572(7770):474-480. doi: 10.1038/s41586-019-1443-5. Epub 2019 Jul 22. PubMed PMID: 31330533.

Vega G, Guequén A, Johansson MEV, Arike L, Martínez-Abad B, Scudieri P, Pedemonte N, Millar-Büchner P, Philp AR, Galietta LJ, Hansson GC, Flores CA. Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium. Front Physiol. 2019 Jun 13;10:694. doi: 10.3389/fphys.2019.00694. eCollection 2019. PubMed PMID: 31263421; PubMed Central PMCID: PMC6585864.

Furter M, Sellin ME, Hansson GC, Hardt WD. Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract. Cell Rep. 2019 May 28;27(9):2665-2678.e3. doi: 10.1016/j.celrep.2019.04.106. PubMed PMID: 31141690; PubMed Central PMCID: PMC6547020.

Hansson GC. Mucus and mucins in diseases of the intestinal and respiratory tracts. J Intern Med. 2019 May;285(5):479-490. doi: 10.1111/joim.12910. Epub 2019 Apr 22. PubMed PMID: 30963635; PubMed Central PMCID: PMC6497544.

Van der Post S, Jabbar KS, Birchenough G, Arike L, Akhtar N, Sjovall H, Johansson MEV, Hansson GC. Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis. Gut. 2019 Mar 26. pii: gutjnl-2018-317571. doi: 10.1136/gutjnl-2018-317571. [Epub ahead of print] PubMed PMID: 30914450.

Birchenough G, Schroeder BO, Bäckhed F, Hansson GC. Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier. Gut Microbes. 2019;10(2):246-250. doi: 10.1080/19490976.2018.1513765. Epub 2018 Sep 25. PubMed PMID: 30252606; PubMed Central PMCID: PMC6546334.

Svensson F, Lang T, Johansson MEV, Hansson GC. The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals. Sci Rep. 2018 Nov 30;8(1):17503. doi: 10.1038/s41598-018-35499-w. PubMed PMID: 30504806; PubMed Central PMCID: PMC6269512.

Fernández-Blanco JA, Fakih D, Arike L, Rodríguez-Piñeiro AM, Martínez-Abad B, Skansebo E, Jackson S, Root J, Singh D, McCrae C, Evans CM, Åstrand A, Ermund A, Hansson GC. Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs. JCI Insight. 2018 Sep 6;3(17). pii: 120994. doi: 10.1172/jci.insight.120994. PubMed PMID: 30185674. PubMed Central PMCID: PMC6171804.

Ermund A, Meiss LN, Dolan B, Bähr A, Klymiuk N, Hansson GC. The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation. Eur Respir J. 2018 Aug 30;52(2). pii: 1800457. doi: 10.1183/13993003.00457-2018.PubMed PMID: 29853489; PubMed Central PMCID: PMC6247115.

Nyström EEL, Birchenough GMH, van der Post S, Arike L, Gruber AD, Hansson GC, Johansson MEV. Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity. EBioMedicine. 2018 Jul 33:134-143. doi: 10.1016/j.ebiom.2018.05.031. PubMed PMID: 29885864; PubMed Central PMCID: PMC6085540.

Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC. Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers. J Biol Chem. 2018 Apr 13;293(15):5746-5754. doi: 10.1074/jbc.RA117.001014. PubMed PMID: 29440393; PubMed Central PMCID: PMC5900763.

Ermund A, Meiss LN, Rodriguez-Pineiro AM, Bähr A, Nilsson HE, Trillo-Muyo S, Ridley C, Thornton DJ, Wine JJ, Hebert H, Klymiuk N, Hansson GC. The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem Biophys Res Commun. 2017 Oct 21;492(3):331-337. doi: 10.1016/j.bbrc.2017.08.113. PubMed PMID: 28859985; PubMed Central PMCID: PMC5596833.

Schroeder BO, Birchenough GMH, Ståhlman M, Arike L, Johansson MEV, Hansson GC, Bäckhed F. Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration. Cell Host Microbe. 2018 Jan 10;23(1):27-40. doi: 10.1016/j.chom.2017.11.004. PMID: 29276171. PubMed Central PMCID: PMC5764785.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C. Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087. PMID: 29166602.

Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC. Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13833-13838. Epub 2016 Nov 14. doi: 10.1073/pnas.1611400113. PubMed PMID: 27849619; PubMed Central PMCID: PMC5137749.

Johansson ME, Hansson GC. Immunological aspects of intestinal mucus and mucins. Nat Rev Immunol. 2016 Oct;16(10):639-49. doi: 10.1038/nri.2016.88. Epub 2016 Aug 8. Review. PubMed PMID: 27498766.

Birchenough GM, Nyström EE, Johansson ME, Hansson GC. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science. 2016 Jun 24;352(6293):1535-42. doi: 10.1126/science.aaf7419. PubMed PMID: 27339979; PubMed Central PMCID: PMC5148821.

Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.