Current Grant Recipients

Current Pilot Project Grant Recipients

2018-2019 Grant Recipients

Impact of Gnotobiosis, Bacterial Metabolomics and Nutrition on Mucosal Immune Cells Pilot Projects

Purpose: To solicit applications for proposed research studies that advance our understanding of immune defense mechanisms and immune regulation at the mucosal surfaces in one of three major areas: a) understanding the impact of microbiota on mucosal immunity using gnotobiotic mice, b) investigating the effects of nutrition on mucosal immune responses, or c) examining how bacterial metabolites can impact mucosal defense mechanisms, including epithelial and immune mediated responses. Full or partial funds were distributed to the most meritorious applications.

Title of Application	PI	Collaborators	Institutions
MIST impact of gnotobiosis, bacterial metabolomics, and nutrition on mucosal immune cells	Hultgren, Scott	Kau, Andrew; Earl, Ashlee	Washington University, Broad Institute of MIT and Harvard
Interactions between the microbiome and MAIT cells	Kronenberg, Mitch	Chu, Hiutung	La Jolla Institute for Allergy & Immunology; University of California at San Diego
Regulation of intestinal homeostasis by commensal microbial B cell superantigens	Bendelac, Albert	Fischbach, Michael	University of Chicago; Stanford University
Innate lymphoid cell- and microbiota- mediated regulation of food allergy	Artis, David	Sonnenberg	Weill Medical College of Cornell
A comparison between diet antigen- and commensal- induced Th17 cells	Cheroutre, Hilde		La Jolla Institute for Allergy & Immunology

MIST Scholar Award in Mucosal Immunity

Purpose: To encourage early stage scientists and/or clinicians to pursue careers in understanding immune defense mechanisms and immune regulation at mucosal surfaces, including respiratory, gastrointestinal and urogenital tract mucosa. A long-term goal of the Mucosal Immunology Studies Team (MIST) is to contribute to the knowledge base needed to facilitate future development of vaccines and immunotherapies to protect mucosal surfaces from infection and immune-mediated pathology. High emphasis was placed on proposed studies that intended to provide a more sophisticated understanding of mucosal immune defense mechanisms, explore novel hypotheses, or address difficult unsolved questions in mucosal immunity and that have the capacity to develop into independently supported projects.

Title of Application	Applicant	Institution
Characterization of sentinel goblet cells and their role as the second line of colonic defence	Birchenough, George	University of Gothenburg (Sweden)
Metabolic control of innate lymphoid cell-mediated lung inflammation	Monticelli, Laurel	Weill Medical College of Cornell
Understanding the role of ClcA1 in mucosal immune defense and mucus secretion in the lung and gut	Herro, Rana	La Jolla Institute for Allergy & Immunology
Defining the phenotype, specificity and transcriptional program of influenza virus infection induced mucosal B cell responses in humans	Ellebedy, Ali	Washington University
Regulation of macrophage activity and colitis by the SMCR8-WDR41-C9ORF72 (SWC) complex	Turer, Emre Erol	UT Southwestern Medical Center
Transmembrane mucins mediate host epithelium monitoring of gut microbiota	Pelaseyed, Thaher	University of Gothenburg (Sweden) www.pelaseyedlab.org
Role of CCL28 in mucosal inflammation	Perez-Lopez, Araceli	University of California at San Diego
Btla Regulation of Germinal Center Responses in the Gut Mucosa	Sedy, John R	Sanford Burnham Prebys Medical Discovery Institute Ware Laboratory
Maternally driven mucosal protection from sepsis in the neonatal intestine	Knoop, Kathryn	Washington University

2017 Grant Recipients

Innovative Collaborations in Mucosal Immunology Pilot Projects

Purpose: To solicit applications for proposed research studies that break new ground in understanding of immune defense mechanisms and immune regulation at the mucosal surfaces, by promoting innovative collaborations among MIST investigators that either 1) foster interactions and scientific dialogue between MIST investigators or 2) bring in outside investigators that will enrich, and benefit the goals of, the MIST consortium. Full or partial funds were distributed to the most meritorious applications.

Title of Application	Co-PI's	Institution
Role of the gut mucosal barrier in restricting the uropathogenic E. coli gastrointestinal reservoir	Hultgren, Scott	Washington University
	Hansson, Gunnar	Göteborg University (Sweden)
Interactions between ILC3 and mucosal CD4 T cells	Sonnenberg, Gregory	Weill Medical College of Cornell
	Cheroutre, Hilde	La Jolla Institute For Allergy & Immunology
TNF superfamily receptors control ILC2 responses	Kronenberg, Mitch	La Jolla Institute For Allergy & Immunology
	Artis, David & Sonnenberg, Gregory	Weill Medical College of Cornell
Mucus produced by Paneth cells, a role for crypt protection	Johansson, Malin & Hansson, Gunnar	Göteborg University (Sweden)
	Bevins, Charles	University of California at Davis
A role for RIP1K in mucosal T cells	Cheroutre, Hilde	La Jolla Institute For Allergy & Immunology
	Kronenberg, Mitch	La Jolla Institute For Allergy & Immunology
Structural basis of microbiota recognition by polyreactive intestinal IgA	Bendelac, Albert	University of Chicago
	Adams, Erin	University of Chicago
Activation of asthma by airway microfold cells	Shiloh, Michael	UT Southwestern Medical Center
	Pasare, Chandrashekhar	UT Southwestern Medical Center
Exposure to house dust mite accelerates lung cancer	Raz, Eyal	University of California at San Diego
	Broide, David	University of California at San Diego

Learn more:

Pilot Project Overview
Application Instructions
Past Grant Recipients
Frequently Asked Questions

Photo: Color enhanced histologic image showing intestinal tissue damage in a murine model of intestinal inflammation. Photo Credit: Artis and Sonnenberg laboratories, Weill Cornell Medical College.