De'Broski Herbert

Nieves W, Hung LY, Oniskey TK, Boon L, Foretz M, Viollet B, Herbert DR. Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection. J Immunol. 2016 Jun 1;196(11):4632-40. doi: 10.4049/jimmunol.1502218. Epub 2016 Apr 20. PubMed PMID:  27183598; PubMed Central PMCID: PMC4875814.

Hung LY, Lewkowich IP, Dawson LA, Downey J, Yang Y, Smith DE, Herbert DR. IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):282-7. doi: 10.1073/pnas.1206587110. Epub 2012 Dec 17. PubMed PMID: 23248269; PubMed Central PMCID: PMC3538196.

Wills-Karp M, Rani R, Dienger K, Lewkowich I, Fox JG, Perkins C, Lewis L, Finkelman FD, Smith DE, Bryce PJ, Kurt-Jones EA, Wang TC, Sivaprasad U, Hershey GK, Herbert DR. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med. 2012 Mar 12;209(3):607-22. doi: 10.1084/jem.20110079. Epub 2012 Feb 13. PubMed PMID: 22329990; PubMed Central PMCID: PMC3302229.

Photo: Immunofluorescence photomicrograph demonstrating the intestinal niche of Nippostrongylus brasiliensis, a hookworm that colonizes the mouse gut and is used to model gastrointestinal nematode infections in humans. Photo Credit: Herbert laboratory, University of Pennsylvania School of Veterinary Medicine.